With the first leg of the 2022 Quarter-Finals set to get underway on April 5 and April 6, there's no better time to hop on betting odds for the Champions League. Just eight teams remain alive at this point of the season, which means we have four high-stakes games just calling—nay, screaming—our names!
And guess what?!? Our latest 2022 Champions League betting predictions will cover every single game and identify the best bets from a stacked list of surviving teams that includes Bayern, Manchester City, Real Madrid, Chelsea and more.
Like always, let's get things started by analyzing the latest online soccer betting odds for the first leg of the 2022 Champions League Quarter-Finals:
| Match Date | Favorite |  | | Underdog |
|---|---|---|---|---|
| 4/5/22 | Manchester City | -240 | +695 | Atletico Madrid |
| 4/5/22 | Liverpool | -260 | +750 | Benfica |
| 4/6/22 | Chelsea | +110 | +265 | Real Madrid |
| 4/6/22 | Bayern Munchen | -122 | +440 | Villarreal |
All these Champions League betting odds are accurate entering Monday, March 21. With roughly two weeks to go until the quarter-finals get started, make sure you're double-checking any betting odds on the 2022 Champions League prior to settling on any picks.
It's likewise a great idea to use the time before matches to pore over our reviews of the top online sportsbooks. We go into extensive detail on each sportsbooks operator so that you'll have no trouble spotting the best Champions League betting sites in 2022.
Atletico Madrid Drawing Dead vs. Manchester City
Atletico Madrid (+695) is usually a defensive powerhouse. Not this season. Their backline has been flimsy and unable to shut down weak-side passes with any sort of consistency. This absence of a shutdown mode at the point-of-attack and in open space has put a ton of pressure on their goalies between the posts.
Among La Liga's top eight teams, in fact, not one of them allowed more scores on the year than Atletico Madrid. Granted, the team's zone defensive schemes have fared better of late; they've conceded just three goals through their past five matches.
But facing Manchester City (-240) is an incredibly tough pull. Even without Kyle Walker (suspended for the first leg of the quarter-finals) and Ruben Dias (thigh injury), they have the depth to upkeep their offensive creativity and precision closer to the crease.
As ever, anything's possible if Atletico Madrid's defense overachieves. But we expect Manchester City to tally at least three goals through regulation in this one. And they might even have an easier time when these two teams face off again in the second leg.
OSB Prediction: Manchester City (-240)
Chelsea Perseveres Against Real Madrid
Chelsea (+110) initially looked like it might fold this season. Their offense struggled amid a League Cup Final loss to Liverpool, and they dealt with a boatload of off-field issues, including drama at the top of the organization with their owner and his ties to Vladamir Putin.
However, Chelsea has refused to go down without a fight. Not only are they working off five straight victories, all of them in fairly convincing fashion, but Kai Havertz, Thiago Silva and Antonio Rudiger are all playing the best soccer of their careers.
On their finest day, Real Madrid (+265) will have a claim to victory. Their defensive schemes are notoriously effective throughout this tournament. But we're a little taken aback that Chelsea is laying better than even money, if we're being honest. Pounce on them now.
OSB Prediction: Chelsea (+110)
Will Liverpool Roll Over Benfica?
Most are going to write off Benfica (+750) from the get go. Oddsmakers sure seem like they've done just that. But Benfica just pulled off a last-16 upset over Ajax. Their ball denial on defense is no joke, and they've shown they can capitalize in a big way off turnovers.
Still, Liverpool (-260) is on an absolute heater at the moment. Over the past 15 games, the Reds are a ridiculous 14-1 and have outscored their opponents 32-5. That is not a typo. That is a real goal differential.
Credit should be paid to Benfica's defense from the point of attack. Jan Vertonghen and Nicolas Otamendi are two of the best to do it right now. For the life of us, though, we can't pretend Benfica has a chance. They don't.
OSB Prediction: Liverpool (-260)
Bayern has the Clear Advantage vs. Villarreal
While Bayern Munich (-122) continues to play like they're distracted by the uncertain future of superstar Robert Lewandowski and a mounting list of injuries, we cannot bring ourselves to pick against them.
Sure, Villarreal (+440) are coming off a wildly entertaining victor over Juventus. But here's the thing: Juventus lacks secondary playmakers. Villarreal was free to put an absurd amount of pressure on the ball at all times. They won't have that same luxury against Bayern—which, for all their struggles, continues to house a handful of high-end decision-makers and shot-takers within their offensive setup.
OSB Prediction: Bayern Munich (-122)
Take a look at this list of the top online sportsbooks so you can decide which one to use for all of your Champions League betting:
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