Can Kansas City Chiefs Hold Off Buffalo Bills on Short Rest in NFL Week 6?

The 2022 NFL season is about to deliver one doozy of an early-year matchup between the Kansas City Chiefs and Buffalo Bills. This head-to-head may determine a great deal about the power structure in the AFC, and it has many of the best online NFL betting sites shifting their odds with more frequency than usual.

There's a reason for this confusion, of course. The Chiefs are coming off shorter rest following their showdown with the Las Vegas Raiders on Monday night in Week 5. On top of that, Patrick Mahomes and crew looked rather lifeless to open up the contest. It had many, including oddsmakers, questioning whether Kansas City would be susceptible to getting hammered by the Bills on Sunday, October 16, at 4:25 p.m. EST.

We share no such concern. But we'll get to that in a second. For now, here's a look at the latest NFL online betting odds for all the games taking place in Week 6, courtesy of the folks over at Bovada:

Favorite			Underdog
Chicago Bears	-112	-104	Washington Commanders
Tampa Bay Buccaneers	-355	+285	Pittsburgh Steelers
Indianapolis Colts	-130	+110	Jacksonville Jaguars
Cincinnati Bengals	-122	+104	New Orleans Saints
Green Bay Packers	-355	+270	New York Jets
Cleveland Browns	-158	+134	New England Patriots
Baltimore Ravens	-235	+194	New York Giants
San Francisco 49ers	-235	+194	Atlanta Falcons
Los Angeles Rams	-500	+385	Carolina Panthers
Arizona Cardinals	-154	+130	Seattle Seahawks
Buffalo Bills	-138	+118	Kansas City Chiefs
Philadelphia Eagles	-220	+184	Dallas Cowboys
Los Angeles Chargers	-255	+210	Denver Broncos

Please note that these NFL betting odds are accurate entering Tuesday, October 11. With Chiefs vs. Bills taking place on October 16, you will want to double-check all football betting lines until you actually place your wager. They will move through the opening kickoff.

Are you among those still in the market for a place to bet on the NFL in 2022? If you are, you've come to the right place. Our reviews of the top online sportsbooks are designed to help you find the best NFL online betting sites for the 2022 season.

Ready? Set? Let's get to our predictions for Kansas City Chiefs vs. Buffalo Bills—including not just the outright winner, but best bets for the Chiefs-Bills point spread and over/under.

The Kansas City Chiefs will Send a Message to the Buffalo Bills

Worrying about the Chiefs coming off short rest is fair. But it's not that short. Kansas City and Buffalo are playing Sunday, not Thursday. The Chiefs also don't have to travel; they'll be playing in Kansas City, just like they were this past week. This isn't that big of deal.

Maybe you're worried the Chiefs needed to come from behind to beat the Raiders in Week 5. That's fine. But let's not pretend this is a chronic issue for them. Their offense hung 44 points on the Arizona Cardinals in Week 1 and 41 points on the Tampa Bay Buccaneers in Week 4. They are built to pick apart any sort of defense, both bad and great.

Indeed, the Bills do have a hellacious defense. It might be better than great. They are sixth in net yards allowed per passing attempt and first in interceptions. But they've also had the benefit of facing a handful of sub-great offenses and quarterbacks. Lamar Jackson of the Baltimore Ravens is by far their toughest opponent thus far, and though Buffalo won, they still allowed leeway through the air.

Going up against Mahomes and the Chiefs is a different test altogether. Buffalo has also somewhat struggled to score on the road. They are averaging 30.4 points per game overall, but that drops to 24.3 away from home.

Suffice it to say, we're shocked the Bills enter this one as favorites. We'll take the Chiefs and their better-than-even money payout, thank you very much.

OSB Prediction: Kansas City Chiefs (+118)

Kansas City Chiefs To beat the Buffalo Bills

+118

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Chiefs are the Easy Point Spread Bet vs. the Bills

Here are the latest point spread betting odds for Chiefs vs. Bills:

Kansas City Chiefs, +2.5 (-110)
Buffalo Bills, 2.5 (-110)

Okay this line is a little tougher to predict. With two of the league's top offenses squaring off, we could absolutely see this turning into a shootout in which both sides are separated by fewer than three points.

Still, 2.5 points is such a small margin, it's statistically smarter to go with whomever you think wins the game. And for us, that's Kansas City.

There is some risk baked in. Kansas City has won both of their home games by a combined four points. (You read that correctly.) But that only means they're do for a game with a larger point differential. And if this contest does indeed turn into a shootout, even a one-possession game could turn into a five-plus-point victory.

OSB Prediction: Kansas City Chiefs, -2.5 (-110)

Kansas City Chiefs To cover the spread vs. the Buffalo Bills

-110

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Is the Over/Under for Kansas City vs. Buffalo Too Ambitious?

You can see the latest over/under betting odds for Kansas City vs. Buffalo in Week 6 below:

Over 53.5 (-110)
Under 53.5 (-110)

Linemakers went the ambitious route with this one. This 53.5 over/under is the largest one in the NFL for Week 6.

Betting the over has not panned out well during Bills games. Those are 1-4, in favor of the under. The Chiefs, on the other hand, are now 3-2 against the over after their win over the Raiders.

Predictably, that makes this a toss-up. But because both offenses are piloted by elite QBs in Mahomes (Chiefs) and Josh Allen (Bills) who throw the ball a crap ton each game, we're assuming one of these squads clears 31 to 33 points.

And if that happens, the over is just a heartbeat away for the other.

OSB Prediction: Over 53.5 (-110)

Chiefs and Bills To score over 53.5 points combined

-110

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Take a look at this list of the top online sportsbooks so you can decide which one to use for all of your 2022 NFL betting: