The 2021 NFL regular season is nearing the halfway point. Can you believe it? More than that, can you believe how much the Super Bowl picture has changed? Surprise teams are in abundance. Devastating setbacks and injuries have reset the expectations for should-be contenders. It’s a bloodbath.
But don’t worry. Our 2021 NFL Week 6 picks with predictions for the Bucs, Chiefs, Packers, Rams, and more seeks to provide you with a sense of betting stability.
With that in mind, let’s check out all the latest NFL betting odds, courtesy BetOnline:
Remember to double-check these NFL odds before settling on any NFL picks. We are putting together these lines just after Monday night football, so the odds will move at BetOnline and other top online sportsbooks.
NFL Week 6 Predictions
As per usual, we will be dropping our best NFL bets from the weekly slate. That means seven NFL predictions from which you can choose.
One thing to bear in mind this week as we dig deeper into these NFL betting lines: If you’re seeing wild swings in how oddsmakers are treating certain squads, such as the New York Giants or Chicago Bears, it’s because of major news developments that propped up after NFL Week 5.
Whenever we make NFL Week 6 picks on one of these games, we will explain the mitigating circumstances should the situation call for it.
Tampa Bay Buccaneers (-305) vs. Philadelphia Eagles (+255)
This matchup is hardly a fair fight.
The Bucs enter at 4-1, averaging 33.4 points per game, the third-most in the NFL. They will be matching up an Eagles defense that ranks in the bottom 10 of points allowed, and a Philadelphia offense that starts second-year quarterback Jalen Hurts under center.
Tom Brady and Co. should have a field day.
OSB Prediction: Tampa Bay Buccaneers (-305)
Green Bay Packers (-210) vs. Chicago Bears (+180)
Oddsmakers are being much easier on the Bears than we would personally be.
Chicago has officially made the shift to rookie QB Justin Fields. While that’s the right move for their future, it puts them in a bind during the short term.
Aaron Rodgers and the Packers should have no problems capitalizing on it. The Bears do sport one of the league’s stingiest defenses, but Green Bay has looked much better since their opening-week disaster.
OSB Prediction: Green Bay Packers (-210)
Kansas City Chiefs (-330) vs. Washington Football Team (+275)
Though we’ve already been burned a couple of times this season by the Chiefs’ moneyline, we are going to come back for more.
Patrick Mahomes remains too damn good, and frankly, Washington is no match for Kansas City. Only one team is currently allowing more points per game than WFT.
People might be quick to say the Chiefs’ own defense can be forgiving, but it isn’t that bad. More importantly, Washington doesn’t have the offensive firepower to win a shootout.
OSB Prediction: Kansas City Chiefs (-330)
Baltimore Ravens (-150) vs. Los Angeles Chargers (+130)
Consider this line a gift...if you’re ready to bet on the Ravens.
Here’s all you need to know: Lamar Jackson currently ranks inside the top 10 of both passing and rushing yards. That is a real stat. In the year 2021. Seriously.
Almost nothing else matters. He’s the best player in the NFL right, and he can carry an entire offense on his own. It helps, of course, that Baltimore’s rush defense again verges on spectacular in most matchups.
OSB Prediction: Baltimore Ravens (-150)
Los Angeles Rams (-1000) vs. New York Giants (+650)
The Giants have been nobody’s favorite bet this season...unless you’re betting against them. But this line appears especially egregious given that the Rams’ offense has fallen back to earth over the past two weeks.
There is, however, an explanation: New York is expected to be without starting quarterback Daniels Jones Jr., who remains in concussion protocols. The Giants already deploy a bottom-seven defense. They can’t afford to just soldier on without their starting QB, too.
OSB Prediction: Los Angeles Rams (-1000)
Cleveland Browns (-150) vs. Arizona Cardinals (+130)
Real question: What in the world is this line?
The Browns have been a fairly pleasant team. Baker Mayfield has them sixth in points per game, and the defense is better than expected.
But the Cardinals are elite. They have a top-six offense and defense. Billing them as underdogs here is wild and feels like an overreaction to star pass rusher Chandler Jones being forced into health and safety protocols.
OSB Prediction: Arizona Cardinals (+130)
Pittsburgh Steelers (-220) vs. Seattle Seahawks (+190)
Far be it from us to pick the Steelers to win any game this season. Except for this one.
The Seahawks will be without star quarterback Russell Wilson in Week 6 and for the foreseeable future as he recovers from a fractured right middle finger. Seattle has the rushing depth to get by, but this isn’t a setback they can just overcome.
We’d recommend pouncing on Pittsburgh before their line moves further in the favorite direction.
OSB Prediction: Pittsburgh Steelers (-220)
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